对于高效高度体积质量转移的疏水原料板式发酵器的CFD评估
Richard Marx1, Huolong Liu1, Seongkyu Yoon1
1Department of Chemical Engineering, University of Massachusetts Lowell, Lowell, Massachusetts, USA.
Biotechnology journal
|February 25, 2024
概括
这项研究使用计算流体动力学 (CFD) 来优化生物制造. 向上的斜叶片驱动器 (PBI) 改善了在酵母发酵中的油分散和质量转移,功率更低.
科学领域:
- 生物技术是生物技术.
- 生物化学工程 生物化学工程
- 计算流体动力学的流体动力学.
背景情况:
- 使用Yarrowia lipolytica的生物制造可以有效地将脂肪转化为高价值产品.
- 预测酵母发酵中的水力动力学和质量转移与分散的油是具有挑战性的,因为高和 sparging.
研究的目的:
- 预测和优化混合动力学和生物制造系统中的质量转移.
- 为了评估螺旋类型,动速度和输入功率对发酵器性能的影响.
主要方法:
- 使用一个商业计算流体动力学 (CFD) 溶解器 (Ansys CFX) 与MUSIG模型.
- 开发了双相 (油/水,空气/水) 和三相 (油,空气,水) 模型来模拟混合和气体分散.
- 研究了不同螺旋类型 (尖叶与Rushton) 和操作条件的影响.
主要成果:
- CFD模拟准确预测了混合动力学和颗粒大小分布.
- 在顶部位置上向上的斜叶叶轮 (PBI) 与Rushton型轮相比,增强了油相同质性.
- 类似的体积质量转移系数 (kL a) 值在使用PBIs降低输入功率时得到.
结论:
- CFD 建模是优化生物制造工艺的宝贵工具.
- 斜叶片驱动器为在Yarrowia lipolytica发酵中实现有效的混合和质量转移提供了更节能的解决方案.
- 这些发现支持改进生物反应器的设计和运行,以提高生物转化效率.
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