双甲和青少年的心脏代谢风险:来自XXI代队列的数据
Vânia Magalhães1, Milton Severo2, Sofia Almeida Costa1
1EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, Portugal; Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
暴露于常见的食品污染物双A (BPA) 的更高水平与青少年心脏代谢风险的增加有关. 这项研究强调了食品接触材料中发现的内分泌干扰物的健康影响.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
背景情况:
- 双A (BPA) 是一种在与食品接触材料中普遍存在的内分泌干扰物.
- 以前的研究表明,BPA暴露与不良健康结果之间存在联系.
研究的目的:
- 估计 Bisphenol A (BPA) 暴露与青少年心脏代谢模式之间的关联.
- 研究食物污染物在青少年健康中的作用.
主要方法:
- 利用了来自葡萄牙第21代出生队伍 (n=2386) 在13岁时的数据.
- 通过24小时尿样 (子样本,n=206) 测量了BPA暴露,并预测了所有参与者使用随机森林,并纳入饮食摄入量.
- 使用高斯混合物模型确定了三种心脏代谢模式 (正常,改性脂质配置,较高的心脏代谢风险),并通过多项回归分析了与BPA水平的关联.
主要成果:
- 较高的BPA暴露与增加的BMIz-score,身体脂肪,腰围,胰岛素血症和三糖血症有关.
- 在对混杂因素进行调整后,在较高的BPA暴露和较高的心脏代谢风险模式 (OR:2.55;95%CI:1.41,4.63) 之间发现了显著的关联.
结论:
- 增加的双甲 (BPA) 暴露显著与青少年心脏代谢风险模式较高有关.
- 这项研究强调了食品污染物对青少年健康问题的贡献.
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