甲基马诱导的甲状腺过高患者的疹:安全的再给药协议
Ferdaous Chahed1, Nadia Ben Fredj1, Haifa Ben Romdhane1
1Department of Clinical Pharmacology, University Hospital/Faculty of Medicine of Monastir, University of Monastir, 5000 Monastir, Tunisia.
概括
甲基马 (MMI) 对于甲状腺功能增强症至关重要. 即使在疹中,MMI也可以安全地使用抗组胺剂的逐步协议重新引入,确保持续的治疗成功.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
背景情况:
- 甲基马 (MMI) 是甲状腺功能增强症的首选治疗方法.
- 疹是MMI的潜在副作用之一.
- 对于接受MMI治疗的患者来说,安全的再给药协议是必不可少的.
研究的目的:
- 报告一系列梅西马诱导的疹病例.
- 为高甲状腺症患者安全重新使用MMI提供一个逐步的协议.
主要方法:
- 追溯11名患有MMI诱导的疹症的患者病例系列.
- 从2013年3月到2022年1月的药监数据.
- 逐步恢复MMI与抗组胺剂的协议.
主要成果:
- 在MMI开始后,11名患者 (SR:0.22) 发生了疹 (中位数为14.5天,中位数剂量为40mg).
- 疹在MMI戒断和抗组胺药物使用后消失.
- 在10/11例患者中,成功地重新引入MMI,使用10天的逐步剂量升级,同时服用 cetirizine.
结论:
- 在高甲状腺患者中,不应仅仅因为甲状腺疹而撤销MMI.
- 逐步重新引入MMI与抗胰岛素支持是有效和安全的.
- 这种方法允许继续MMI治疗和成功的甲状腺功能增强症管理.
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