通过使用静止状态功能连接体来研究高血压对血管认知障碍的影响
Tai-Hsin Hung1,2, Vincent Chin-Hung Chen1,2, Yu-Chen Chuang3,4
1School of Medicine, Chang Gung University, Taoyuan, Taiwan.
Scientific reports
|February 25, 2024
概括
高血压与血管认知障碍有关,影响大脑活动和连接能力,特别是在额头和顶部区域. 这项研究显示,高血压患者的大脑功能发生改变,影响认知能力.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 高血压 (HTN) 影响全球超过12亿人,定义为静缩血压 (BP) ≥140 mmHg和静缩血压≥90 mmHg.
- 高血压是脑血管疾病的主要危险因素,可能导致血管认知障碍 (VCI).
- VCI表现为执行功能障碍,这是血管痴呆症的过渡阶段,需要可靠的诊断方法.
研究的目的:
- 为了研究VCI的高血压个体休息状态功能连接体的变化.
- 在高血压的背景下,确定受VCI影响的特定大脑区域.
- 为了将神经成像发现与观察到的认知缺陷相关联.
主要方法:
- 利用低频波动的幅度 (ALFF) 和区域同质性 (ReHo) 来评估自发的大脑活动.
- 使用图形理论分析 (GTA) 和基于网络的统计 (NBS) 来分析功能连接.
- 对比28名高血压患者 (51-83岁) 与28名健康对照 (51-75岁).
主要成果:
- 高血压患者在代谢受损区域的自发活动减少,体感和前额叶皮层的活动增加.
- 在HTN组中观察到执行功能,处理速度和记忆中的认知缺陷.
- GTA和NBS揭示了复杂的局部隔离,全球整合受损,HTN功能连接受损.
结论:
- 休息状态的功能连接在潜在的VCI的高血压个体中显著改变.
- 变化特别突出在前脑和脑区域.
- 研究结果强调了高血压对大脑网络和认知功能的影响.
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