荷兰和南亚苏里南的肠道微生物群的差异:对2型糖尿病的潜在影响
Eric I Nayman1,2, Brooke A Schwartz3,4, Michaela Polmann3
1Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. enaym001@fiu.edu.
Scientific reports
|February 25, 2024
概括
荷兰的肠道微生物群体显示出与南亚苏里南姆 (SAS) 群体相比,更相互关联的微生物生态和多样化的短链脂肪酸 (SCFA) 生产者. 在SAS组中,这种肠道失调可能与其较高的2型糖尿病 (T2DM) 患病率有关.
科学领域:
- 人类微生物组研究研究
- 肠道微生物生态学
- 代谢性疾病的关联
背景情况:
- 肠道微生物群对人类健康有重大影响,短链脂肪酸 (SCFA) 生产减少与2型糖尿病 (T2DM) 有关.
- 现有的微生物组研究往往忽视少数民族人口,造成知识差距.
- 在T2DM患病率上存在种族差异,这表明潜在的潜在生物学差异,包括肠道微生物组合.
研究的目的:
- 调查少数民族 (荷兰人) 和少数民族 (南亚苏里南人 - SAS) 之间的肠道微生物组成和生态模式的差异.
- 探索肠道微生物特征与这些群体中T2DM不同患病率之间的关联.
- 为了识别潜在的微生物生物标志物区分种族群体.
主要方法:
- 从城市环境中的健康生活 (HELIUS) 队列中分析微生物组数据,比较年龄和性别匹配的荷兰 (n=41) 和 SAS (n=43) 个人.
- 使用DADA2确定微生物群落组成,并计算多样性和相似性指标.
- 生物标志物分析和细菌共发生网络建设,以评估生态模式和识别歧视性分类.
主要成果:
- 在荷兰妇女中观察到一个独特的微生物群,在SAS个体中有一些重叠.
- 荷兰的肠道微生物群体表现出与SAS集团分散网络相比,更相互连接的微生物生态.
- 在荷兰,包括SCFA生产者如Bacteroides caccae和Alistipes putredinis在内的特定类型被丰富,而Haemophilus和Bifidobacterium则歧视SAS集团.
结论:
- 荷兰肠道微生物群的特点是多样化,差异丰富的SCFA生产分类,具有显著的分类学间合作,与SAS群不同.
- 在SAS群体中观察到的肠道失调和不那么动态的微生物生态可能导致他们对T2DM的更高倾向.
- 海莫菲勒斯 (Haemophilus parainfluenzae) 已成为少数民族群体的潜在生物标志物,与较高的T2DM风险有关.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Anatomy of the Intestines
71.9K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.9K
Pathophysiology of Diabetes
935
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
935
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
What is Monogastric Digestion?
71.2K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.2K
Irritable Bowel Syndrome I: Introduction
274
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
274


