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Updated: Jul 2, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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2',3'-受保护的核酸作为酶 de novo RNA 合成的构建块

Maëva Pichon1, Fabienne Levi-Acobas1, Camélia Kitoun1

  • 1Institut Pasteur, Université Paris Cité, CNRS UMR3523, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, 28, rue du Docteur Roux, 75724, Paris Cedex 15, France.

Chemistry (Weinheim an der Bergstrasse, Germany)
|February 25, 2024
PubMed
概括

研究人员开发了一种用于合成RNA寡核酸的新型酶方法. 这种方法使用具有模板独立RNA聚合酶的受保护的pyrimidine核酸,使得治疗应用的快速,受控的RNA构造成为可能.

关键词:
这是一个RNARNARNARNARNA.控制的酶合成酶.在 de novo RNA 合成中.修改后的核酸.聚合酶的聚合物

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