在患有血液恶性病的患者中确定感染性腹的危险因素
Şükran Şahinkaya1, Zeynep Ture2, Ali Unal3
1Department of Infection Control Committee, Erciyes University, Kayseri, Turkey.
Infection & chemotherapy
|February 25, 2024
概括
皮质类固醇使用增加了患有血液性恶性瘤的患者感染性腹的风险,而颗粒细胞殖民地刺激因子 (GCSF) 提供了保护作用. 传染性腹在这些患者中也往往持续更长时间.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 血液性恶性瘤通常需要化疗或造血干细胞移植.
- 这些治疗可能会导致腹等并发症.
- 确定传染性腹的危险因素对于患者管理至关重要.
研究的目的:
- 确定在接受血液性恶性瘤治疗的患者中与传染性腹相关的危险因素.
- 为了比较感染性腹和未识别腹的患者的特征和结果.
主要方法:
- 展望性,观察性研究设计.
- 通过实验室确认的致病原体定义的传染性腹.
- 人口统计数据,治疗方法,风险因素和传染性和未识别的腹组之间的预后的比较.
主要成果:
- 在838名住院患者中,105名 (12.5%) 符合纳入标准.
- 困难菌是最常见的传染病原体 (12.4%).
- 感染性腹组的皮质类固醇使用明显高 (39.5%对7.5%),而花细胞殖民地刺激因子 (GCSF) 的使用在未确定的腹组更高 (67.2%对42.1%).
- 传染性腹持续时间更长 (中位数为9天而不是5天).
- 多变量分析显示,皮质类固醇治疗增加了4.75倍的传染性腹风险,而GCSF具有保护作用 (降低风险0.35倍).
结论:
- 在患有血液性恶性瘤的患者中,传染性腹比未确定的腹更长时间.
- 皮质类固醇使用是发展传染性腹的重要危险因素.
- 颗粒细胞殖民地刺激因子 (GCSF) 的使用显示出对感染性腹的保护作用.
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