饮食中的亚毒素暴露,环境肠道病变,以及它们与儿童发育迟缓的关系
Markos Makiso Urugo1,2, Tilahun A Teka2, Tefera Belachew Lema3
1Department of Food Science and Postharvest Technology, College of Agricultural Sciences, Wachemo University, Hosaina, Ethiopia.
International journal of food sciences and nutrition
|February 26, 2024
概括
在5岁以下的儿童中,阿弗拉托克辛暴露会影响肠道健康,可能导致发育迟缓. 通过改进的做法,减少对亚拉托克辛的暴露,可以帮助预防儿童发育迟缓和环境肠病.
科学领域:
- 全球健康 全球健康
- 毒理学 毒理学 毒理学
- 儿科 儿科 儿科
背景情况:
- 儿童发育迟缓影响全球超过1.49亿名儿童.
- 阿弗拉托克素 (AF) 暴露与肠道微生物组的破坏,肠道功能障碍和衰老有关.
- 环境肠病 (EE) 是一种影响营养吸收的疾病.
研究的目的:
- 探索AF暴露,EE和儿童衰退之间的关系.
- 审查AFs对EE和衰老的贡献机制.
- 提出干预策略,以减少AF暴露,EE和衰老.
主要方法:
- 关于AFs,肠道微生物组,EE和儿童发育迟缓的研究的文献综述.
- 对AFs影响DNA和蛋白质合成的分子机制的分析.
- 综合证据,将AF诱导的EE与营养吸收和吸收不良的相关证据.
主要成果:
- AFs可以通过改变微生物组和引起EE来破坏肠道健康.
- EE会损害肠道细胞,导致吸收不良并导致发育迟缓.
- 从AF暴露到肠道功能障碍和衰老有一个明显的途径.
结论:
- 减少AF暴露对于预防儿童发育迟缓至关重要.
- 干预措施应针对减少暴露,农业实践,饮食和卫生条件.
- 全球需要综合战略来打击AF,EE和衰老.
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