在甲状腺切除术后使用静脉注射布洛芬和乙氨基联合治疗术后的术后疼痛管理与单独使用乙氨基相比:一项前性随机对照试验
Jaesik Park1, Do Kyung Lee1, Ji Eun Kim1
1Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Head & neck
|February 26, 2024
概括
结合静脉注射的乙氨基和布洛芬显著减少甲状腺切除术后的急性术后疼痛,而不是单独使用乙氨基. 这种组合疗法为患者提供了改善的疼痛管理.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 手术疼痛管理手术疼痛管理
背景情况:
- 术后疼痛管理往往需要多模式止痛药以获得最佳的疗效.
- 研究组合止痛药的协同效应对于改善患者康复至关重要.
- 甲状腺切除术对急性疼痛控制具有特殊的挑战,因为它的位置和潜在的严重不适.
研究的目的:
- 为了评估结合静脉注射乙氨基和布洛芬治疗方案与单独乙氨基治疗甲状腺切除术后立即术后疼痛的有效性.
- 为了比较两个治疗组之间的疼痛强度的减少和需要阿片类救援药物的需要.
主要方法:
- 这是一项双盲随机临床试验,涉及62名接受甲状腺切除术的患者.
- 患者接受了静脉注射的乙氨基 (1000毫克) 加上布洛芬 (300毫克) 或单独服用乙氨基 (1000毫克).
- 使用视觉模拟尺度 (VAS) 评估疼痛后0,15分钟和30分钟恢复室入院;阿片类药物消费也被记录下来.
主要成果:
- 与对照组相比,组合组在服用后15分钟和30分钟显示出明显较低的VAS得分 (p < 0.05).
- 接受联合治疗的患者需要显著减少阿片类救援药物 (p = 0.033).
结论:
- 静脉注射的乙氨基和布洛芬联合治疗显示,在甲状腺切除术后的急性术后疼痛管理中,乙氨基单独治疗的疗效优于乙氨基单独治疗.
- 这种多模式的方法可能是一个有价值的策略,可以改善立即缓解疼痛并减少甲状腺切除术患者的阿片类药物依赖.
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