在接受治疗的牛皮患者中,基础细胞癌的风险是否会增加?
Gülcan Aliye Sevdem1, Kucuk Su Ozlem1, Yilmaz Nazan1
1Bezmialem Vakif University, Fatih/İstanbul, Turkey.
Photodermatology, photoimmunology & photomedicine
|February 26, 2024
概括
牛皮患者患基底细胞癌 (BCC) 的风险更高. 对牛皮的长期PUVA治疗增加了这种风险,强调了在这些人中管理皮肤癌时需要保持警.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,与各种并发症有关,包括增加癌症患病率.
- 虽然状细胞癌与牛皮有关,但基底细胞癌 (BCC) 的数据有限.
研究的目的:
- 在患有牛皮的患者中调查基细胞癌 (BCC) 的患病率和危险因素.
- 为了比较牛皮患者和对照组之间的BCC发病率.
主要方法:
- 分析了346名牛皮患者和306名对照患者的队列,根据年龄和性别进行了匹配.
- 基础细胞癌 (BCC) 诊断通过可疑病变的活检通过组织病理学证实.
- 使用牛皮区域和严重程度指数 (PASI) 评估牛皮的严重程度,并记录了治疗方法.
主要成果:
- 在牛皮患者 (6.6%) 中,基础细胞癌 (BCC) 的发生率明显高于对照组 (2.9%).
- 晚年,吸烟和牛皮关节炎被确定为牛皮患者BCC的危险因素.
- 长期的UVA (psoralen加紫外线A) 治疗,但不是NB-UVB,与BCC的风险增加有关.
结论:
- 牛皮与患基底细胞癌 (BCC) 的风险增加有关.
- 牛皮患者的BCC风险在长时间接触PUVA治疗时尤为明显.
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