[基于倾向性得分匹配的危急病患者静脉血栓塞栓症威尔布兰德因子的预测值]
Jinxi Yue1, Linjun Wan, Gang Wang
1Department of Critical Care Medicine, the Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, China. Corresponding author: Ren Zongfang,
Zhonghua wei zhong bing ji jiu yi xue
|February 26, 2024
概括
·威尔布兰德因子 (vWF) 可以预测重症监护室 (ICU) 患者的静脉血栓塞栓症 (VTE). 在ICU入院后48小时监测vWF水平对于预测VTE风险非常有价值.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 血管生物学 血管生物学
背景情况:
- 静脉血栓塞栓症 (VTE) 是重症监护室 (ICU) 患者的重大并发症.
- 早期预测VTE对于及时干预和改善患者结果至关重要.
研究的目的:
- 评估·威尔布兰德因子 (vWF) 对ICU患者静脉动脉突发症的预测能力.
- 使用倾向分数匹配 (PSM) 来控制分析中的混因素.
主要方法:
- 分析了120名长期住院 (≥72小时) 和每日超声波查的ICU患者队列.
- 倾向性得分匹配 (PSM) 用于平衡VTE和非VTE组之间的基线特征.
- 使用多变量逻辑回归和ROC曲线分析来评估vWF的预测值.
主要成果:
- 在PSM之后,分析了14对匹配对,显示出平衡的共变量.
- 在ICU入院后48小时,增加的vWF水平被确定为VTE的独立风险因素 (OR=1.165,P=0.004).
- 接收器操作特征 (ROC) 曲线分析显示,vWF具有显著的预测值 (AUC=0.782,P=0.007) 具有高特异性 (93.0%).
结论:
- 动态监测vWF水平有助于预测重症患者的VTE.
- 在ICU入院48小时后测量的vWF显示了VTE风险分层的显著潜力.
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