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在法医领域测量酸盐离子的纸质电化学带的技术评估

Ada Raucci¹, Antonella Miglione¹, Wanda Cimmino¹

¹Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.

ACS measurement science au

|February 26, 2024

概括

本研究介绍了一种便携式电化学装置,用于准确检测生物样本中的酸盐. 这项创新有助于在涉嫌酸盐中毒的情况下进行法医调查.

科学领域:

分析化学分析化学
电化学电化学电化学
法医科学法医科学法医科学

背景情况:

酸盐是一种多用途的化合物,具有工业,制药和食品添加剂应用.
它的高毒性和可访问性导致其在杀人和自杀中使用.
准确检测生物流体中的酸盐对于法医毒理学至关重要.

研究的目的:

开发和验证一种基于纸张的电化学装置,用于选择性化物测定.
评估设备在复杂的生物矩阵中对法医病例相关的性能.

主要方法:

开发一种基于纸张的电化学装置,用于化物检测.
使用线性,选择性和灵敏度等参数验证设备.
用标准色谱方法比较结果.
在各种生物流体中测试设备:血液,尸体血液,玻璃体,血清,血和尿液.

主要成果:

该设备显示了微分子范围内的线性反应.
在缓冲溶液中实现了0.4μM的检测极限.
生物流体中的特定检测极限在1至5μM之间.
与染色学方法相比,准确度令人满意,在91%至112%之间.

结论:

开发的基于纸张的电化学装置提供了一种简单,便携和敏感的化物检测方法.
它在复杂生物流体中的性能使其适用于法医应用,特别是在疑似酸盐中毒的情况下.

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