在北欧成年人中确定可溶性尿素酶等离子体激活剂受体的参考间隔
Stine Bakkensen Bruun1, Jeppe Buur Madsen1, Claus Lohman Brasen1,2
1Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100, Vejle, Denmark.
Practical laboratory medicine
|February 26, 2024
概括
这项研究通过使用快速粒子增强度测试免疫试验 (PETIA) 建立了可溶性尿素酶等离子素激活器受体 (suPAR) 的新参考间隔. 这些发现支持suPAR的性别特定参考范围,这对于紧急医疗应用至关重要.
科学领域:
- 临床诊断 临床诊断 临床诊断
- 生物标志物的分析分析.
- 免疫测试是一种免疫测试.
背景情况:
- 可溶性泌尿酸酶等离子体激活受体 (suPAR) 显示出诊断潜力.
- 使用较慢的酶相关免疫试验确定了suPAR的现有参考间隔.
- 在紧急医疗环境中,需要更快的测量来进行suPAR分析.
研究的目的:
- 用完全自动化的粒子增强型度测量免疫试验 (PETIA) 来确定suPAR的参考间隔.
- 为suPAR建立性别分区的参考间隔.
- 为了与临床和实验室标准协会指南A28-A3c对测试验证进行一致.
主要方法:
- 从241名健康的丹麦献血者的血中分析了suPAR水平.
- 在cobas 8000自动化系统上使用了粒子增强的流测量免疫试验 (PETIA).
- 以性别为特征的参考间隔是使用参数定量方法计算的.
主要成果:
- 对suPAR的共同参考间隔为1.56-4.11 ng/mL.
- 建立了按性别划分的参考间隔:女性1.59-4.65 ng/mL,男性1.56-3.59 ng/mL.
- 对于所有计算的参考值,确定了95%的置信区间.
结论:
- 这项研究验证了对suPAR的性别分区参考间隔的使用.
- 开发的PETIA方法为未来的suPAR研究提供了基础.
- 这些发现支持suPAR在诊断中的临床实用性,特别是在快速检测方法中.
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