接种SARS-CoV-2疫苗和精液质量:基于中国西南部精子捐赠者候选人数据的研究
Tingting Yang1,2, Die Tang3, Yu Zhan3
1Department of Andrology/Human Sperm Bank of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, China.
Translational andrology and urology
|February 26, 2024
概括
在男性中,COVID-19疫苗接种对大多数精子质量参数没有显著影响. 虽然一些运动性指标显示了暂时的差异,但个体变异性是影响精子健康疫苗接种后的主要因素.
科学领域:
- 生殖医学 生殖医学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 由于COVID-19的流行,全球疫苗接种工作变得必不可少.
- 有关严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 疫苗对人类生育能力的影响存在担忧.
- 关于COVID-19疫苗接种对男性生殖健康的影响的数据有限.
研究的目的:
- 为了调查COVID-19疫苗接种和男性生育能力之间的关联.
- 分析疫苗接种后精子参数在精子捐赠者队列中的变化.
主要方法:
- 在2020年1月至2021年12月期间接种疫苗的564名中国精子供体候选人中进行了一项观察性研究.
- 分析了2,955个精液样本,重点是接种疫苗前后提供样本的个人.
- 统计分析包括韦尔奇两样本测试和混合效应回归模型.
主要成果:
- 虽然一些精子运动参数在接种疫苗之前和之后显示出统计学上显著的差异,但混合效应模型表明与精子质量没有关联,除了曲线速度 (VCL),平均路径速度 (VAP) 和直线速度 (VSL) 之外.
- 个人变异性被确定为精子质量变异的主要决定因素,占19%至82%的比例.
结论:
- 在统计学上,COVID-19疫苗接种似乎与整体精子质量显著下降无关.
- 个体的生物变异对精子质量起着至关重要的作用.
- 这些发现有助于了解大流行期间的男性生殖健康.
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