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系统性免疫炎症指数与COPD呼吸衰竭和死亡风险之间的关系:基于MIMIC-IV数据库的回顾性队列研究
Ye Zhang1, Xiaoli Tan2, Shiyu Hu3
1Department of General Medicine, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, People's Republic of China.
International journal of chronic obstructive pulmonary disease
|February 26, 2024
概括
系统性免疫炎症指数 (SII) 预测慢性阻塞性肺病 (COPD) 患者的治疗结果不佳. 较高的SII水平与呼吸衰竭 (RF) 和死亡率的风险增加有关,有助于风险分层.
科学领域:
- 肺部医学 肺部医学
- 关键护理医学 关键护理医学
- 生物标志物研究 生物标志物研究
背景情况:
- 慢性阻塞性肺病 (COPD) 与呼吸衰竭 (RF) 导致显著的死亡率和残疾.
- 系统性免疫炎症指数 (SII) 是一种与心血管和脑血管疾病不良结果相关的新生物标志物.
- 在COPD中SII的预后价值仍未得到充分研究.
研究的目的:
- 评估SII在预测COPD患者预后方面的准确性.
- 评估SII水平与COPD患者的RF发生率和死亡率之间的关联.
主要方法:
- 从密集护理-IV (MIMIC-IV) 数据库中对临床数据的回顾性分析.
- 包括1653名被诊断患有COPD的患者.
- 利用考克斯的比例风险模型,受限立方线和卡普兰-梅尔分析来检查SII和结果 (RF,住院死亡率,长期死亡率) 之间的关系.
主要成果:
- 在COPD患者中,较高的SII水平与RF风险增加 (HR:1.19),住院死亡率 (HR:1.22) 和长期死亡率 (HR:1.12) 有显著的关联.
- 卡普兰-梅尔分析显示,随着SII升高,所有死因的风险显著增加,特别是在21天内.
- 在1653名患者中,42.2%患有RF,10.2%在住院期间死亡,38.5%在长期随访期间死亡.
结论:
- 系统性免疫炎症指数 (SII) 与COPD患者呼吸衰竭和死亡率的风险增加密切相关.
- SII显示出作为COPD预后预测器的潜力,对风险分层有用.
- 建议进行进一步的前性研究来验证这些发现.
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