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使用功能性磁共振成像来评估与静止疼痛相关的大脑激活,用于接受膝关节手术的Cynomolgus
Hatsumi Ichinose1, Takahiro Natsume2, Mizuho Yano2
1Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Journal of orthopaedics
|February 26, 2024
概括
功能性磁共振成像 (fMRI) 揭示了在膝盖手术后,与疼痛相关的区域的大脑激活显著. 这项研究证明了fMRI.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 灵长类动物模型
背景情况:
- 功能磁共振成像 (fMRI) 是可视化大脑活动的关键工具.
- 通过检测显著的大脑激活,fMRI已经被用来客观地评估各种疼痛条件.
- 了解非人类灵长类动物的疼痛机制对于翻译研究至关重要.
研究的目的:
- 在Cynomolgus macaques中建立一个术后疼痛模型.
- 使用fMRI确认膝盖手术后与休息疼痛相关的大脑激活.
- 调查fMRI在评估术后疼痛方面的实用性.
主要方法:
- 骨质粒体移植手术是在四只Cynomolgus的股骨上进行的.
- 脑部fMRI是在手术前,手术后和吗啡后进行的.
- 在fMRI分析中,统计学意义被定义为Z值>1.96.6.
主要成果:
- 术后的fMRI显示,与手术前水平 (1.05和1.03) 相比, cingulate皮层 (3.09) 和岛屿皮层 (3.06) 的激活显著增加.
- 这些激活在没有直接刺激的情况下观察到与疼痛相关的大脑区域.
- 吗啡的使用导致 cingulate 皮层 (1.38) 和 insular 皮层 (1.21) 的激活减少.
结论:
- 骨质突变移植手术可以诱导的显著休息疼痛.
- fMRI有效地识别了与膝盖手术相关的疼痛通路中的大脑激活.
- fMRI是评估灵长类模型中手术后疼痛的宝贵工具.
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