乳酸脱酶的升高预测在自发性脑内出血时的肺炎
Yangchun Xiao1, Shuanghong He2, Xin Cheng3
1Department of Neurosurgery, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Heliyon
|February 26, 2024
概括
乳酸脱酶水平升高预测自发脑内出血患者的肺炎风险. 这种炎症生物标志物可能有助于识别需要密切监测肺炎发展的患者.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 生物标志物 生物标志物
背景情况:
- 肺炎是自发性脑内出血 (ICH) 后的一个常见并发症.
- 已经确定了ICH后肺炎的现有风险因素,但仍然需要一个客观,易于获得的预测因素.
- 乳酸脱酶 (LDH) 是一种具有潜在预测价值的非特异性炎症生物标志物.
研究的目的:
- 研究血清乳酸脱酶水平与自发性ICH患者肺炎发病率之间的关联.
- 评估LDH作为这种患者群体中肺炎的潜在早期预警标志物.
主要方法:
- 一项回顾性多中心队列研究,涉及7562名自发性ICH患者.
- 在入院后7天内测量血清LDH水平,并将其分为四分位数.
- 采用多变量逻辑回归分析来评估LDH水平与肺炎发展之间的关联.
主要成果:
- 在7562名患者中,有39.3%的患者被诊断出肺炎.
- 在所有等级中,LDH水平升高与肺炎风险增加显著相关.
- 后勤回归显示,当LDH被视为连续变量时,肺炎的几率比率增加,具有较高的LDH四分位数 (Q2-Q4 vs. Q1) 和大幅调整的几率比率 (4.42).
结论:
- 乳酸脱酶的升高是自发性ICH患者肺炎的显著预测因素.
- LDH对包括严重病例在内的肺炎具有预测价值,可以作为一种有用的实验室标记物,用于识别有风险的个体.
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