植入期间的雌激素水平对体外受精胚胎移植妊娠结果没有影响
Pinxiu Huang1,2,3,4,5, Yuan Ou1,2,3,4,5, Ni Tang1,2,3,4,5
1Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center-Liuzhou Hospital, Liuzhou, Guangxi, China.
Frontiers in endocrinology
|February 26, 2024
概括
在体外受精-胚胎移植 (IVF-ET) 过程中可能不需要监测质雌激素 (E2) 水平. 研究结果表明,HCG触发后第11天的E2水平不会显著影响IVF-ET结果,包括活产率.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 临床产科和妇科 临床产科和妇科
背景情况:
- 在体外受精-胚胎移植 (IVF-ET) 过程中监测质内分泌功能的必要性受到争议.
- 具体来说,黄体阶段雌激素 (E2) 水平的意义是当前文献中争议的一个点.
研究的目的:
- 评估HCG触发后第11天质期雌激素 (E2) 水平对IVF-ET结果的影响.
- 为了确定中期和晚期黄质期血清E2 (MllPSE2) 水平是否影响临床怀孕,堕胎和活产率.
主要方法:
- 对12535次IVF-ET周期 (2015-2021) 的回顾性分析.
- 循环被分为五组,根据MllPSE2水平 (11日HCG触发后).
- 使用二进制逻辑回归,在不同组中比较临床怀孕率,堕胎率和活产率 (LBR).
主要成果:
- 在五组中没有观察到临床怀孕,堕胎或活产率的显著差异.
- 在孕妇和非孕妇组之间,MllPSE2水平没有显著差异.
- 二进制逻辑回归证实MllPSE2与LBR没有显著的关系.
结论:
- 在HCG触发后的第11天的雌激素水平似乎不会显著影响IVF-ET的结果,即使低于50 pg/mL.
- 在植入期期间,卵巢衍生的E2可能对子宫内膜接受性没有必要.
- 在IVF-ET中常规监测质E2可能具有可疑的临床价值,需要进一步调查.
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