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自身免疫性甲状腺疾病和肌痛性肌痛症:一项双向研究 门德尔的随机化
Suijian Wang1, Kui Wang2, Xiaohong Chen1
1Department of Endocrinology, The First Affiliated Hospital, School of Medicine, Shantou University, Shantou, China.
Frontiers in endocrinology
|February 26, 2024
概括
自身免疫性甲状腺疾病 (AITD) 增加了对肌痛性硬化症 (MG) 的易感性. 相反,格雷夫斯病 (GD),是一种AITD,与MG有因果关系,而自身免疫性甲状腺功能低下症显示出不稳定的关联.
科学领域:
- 内分泌学和免疫学.
- 遗传流行病学遗传流行病学
背景情况:
- 以前的研究表明,自身免疫性甲状腺疾病 (AITD) 和肌痛性肌痛症 (MG) 之间存在联系,但证据有限且有争议.
- AITD和MG之间的确切因果关系仍然不确定,需要进一步调查.
研究的目的:
- 使用孟德尔随机化 (MR) 方法调查AITD和MG之间的潜在因果关系.
- 为了澄清AITD和MG之间的协会的指导性.
主要方法:
- 利用全基因组关联研究 (GWAS) 在欧洲祖先的总结统计数据进行MR分析.
- 采用多种MR技术,包括逆方差加权 (IVW),加权中位数,MR-Egger回归和MR-PRESSO,以确保结果的稳定性.
- 通过使用科克兰的Q值来评估异质性,并通过MR-Egger回归和MR-PRESSO来研究水平变性.
主要成果:
- 通过IVW方法表明,格雷夫斯病 (GD) 和MG (OR 1.31) 以及自身免疫性甲状腺功能低下症和MG (OR 1.26) 之间存在因果关系.
- 反向MR分析证实了MG和GD (OR1.50) 之间的因果关系,但显示了MG和自身免疫性甲状腺功能低下症之间的不稳定关联,这是由于水平类型.
- MG显示甲状腺过氧化酶抗体 (TPOAb) 阳性 (OR 1.84) 的患病率较高,以及与提升的TSH水平 (Beta:0.08) 的潜在联系.
结论:
- 患有自身免疫性甲状腺疾病的患者表现出对发展肌痛性硬化症 (myasthenia gravis) 的敏感性增加.
- 骨髓灰质炎患者表现出更高的格雷夫斯病发病率,这表明双向关系.
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