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保存的C-是常见的,并且与中国1型糖尿病的更高的时间范围有关
Wei Liu1, Yayu Fang1, Xiaoling Cai1
1Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, ;China.
Frontiers in endocrinology
|February 26, 2024
概括
很大一部分患有1型糖尿病 (T1D) 的中国患者保持C-分泌. 这种保存的C-与更好的血糖控制有关,突出显示需要治疗来维持T1D中的β细胞功能.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 糖尿病研究 糖尿病研究
背景情况:
- 1型糖尿病 (T1D) 的特征是胰腺β细胞的自身免疫破坏.
- 剩余的C分泌是T1D中贝塔细胞功能剩余的指标.
- 了解C-水平对于评估疾病进展和治疗疗效至关重要.
研究的目的:
- 为了确定T1D的中国个体的残留C水平.
- 调查保存的C-分泌对血糖控制的临床意义.
- 为了确定与随着时间的推移C损失相关的因素.
主要方法:
- 在534名中国T1D患者的横截面和纵向研究中.
- 参与者分为低C (≤10 pmol/L) 和保存的C (>10 pmol/L) 组.
- 对与C-损失相关的因素进行考克斯回归分析;分析了持续葡萄糖监测 (CGM) 数据.
主要成果:
- 缺乏保存的C与更长的糖尿病持续时间,GAD自身抗体和更高的胰岛素剂量相关.
- 纵向分析显示,在5年内,保存的C-的百分比不同 (22.2%-71.7%).
- 保存的C-与CGM的显著更高的范围时间 (TIR) 有关 (调整后P = 0.003).
结论:
- 在中国的T1D患者中,很大一部分患者表现出保存的C-分泌物.
- 剩余的C-与有利的血糖控制有关,特别是改善了范围内的时间.
- 进一步研究旨在保护T1D中的β细胞功能的辅助疗法是有必要的.
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