低甲状腺功能与代谢功能障碍相关的脂肪性肝病有关.
Shuo Wang1, Ding Xia1,2, Hong Fan1
1Department of Epidemiology, School of Public Health Fudan University Shanghai China.
JGH open : an open access journal of gastroenterology and hepatology
|February 26, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与甲状腺功能低下有关. 这种关联是独立的,突出显示甲状腺健康状况.
科学领域:
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个新术语,强调心脏代谢功能障碍的作用.
- MASLD取代非酒精性脂肪肝疾病,以更好地反映代谢链接.
研究的目的:
- 为了研究甲状腺功能低下和MASLD之间的关联.
- 在更新的MASLD背景下检查这种关系.
主要方法:
- 一项回顾性队列研究包括从2016年到2021年的2901名参与者.
- 参与者根据甲状腺刺激激素 (TSH) 水平分为严格正常和低甲状腺功能组.
- 考克斯回归模型分析了危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 严格正常甲状腺功能组的8.9%和甲状腺功能低下组的13.4%患有MASLD.
- 甲状腺功能低下 (HR 1.53) 和亚临床甲状腺功能低下 (HR 1.95) 与MASLD显著相关.
- 这种关联仍然具有统计相关性 (P < 0.05).
结论:
- MASLD与甲状腺功能低下显著相关.
- MASLD和低甲状腺功能之间的关系是独立的.
- 甲状腺功能是MASLD发展的一个重要因素.
相关概念视频
Overview of Lipid Metabolism
1.6K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.6K
Liver Physiology
547
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
547
Diseases of the Liver and Gallbladder
538
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
538
Chronic Pancreatitis I: Introduction
89
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
89
Cholesterol: Significance and Regulation
544
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
544
Overview of Carbohydrate Metabolism
1.0K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.0K


