揭示了两种Bos taurus牛品种的选择结构
Troy N Rowan1,2,3,4, Robert D Schnabel1,2,5, Jared E Decker1,2,5
1Division of Animal Sciences University of Missouri Columbia Missouri USA.
Evolutionary applications
|February 26, 2024
概括
我们开发了一种新的方法来绘制牛基因组中最近的多基因选择. 这种方法确定了数百个与重要特征相关的选定基点,揭示了养品种中复杂的选择模式.
科学领域:
- 动物遗传学 动物遗传学
- 基因组选择 基因组选择
- 进化生物学是进化的生物学.
背景情况:
- 定向选择通过扫描和多基因选择来塑造基因组.
- 由于细微的基因组签名,绘制多基因选择具有挑战性.
- 暂时分层的基因型可以检测最近的定向等位基因频率变化.
研究的目的:
- 应用代代选择映射 (GPSM) 方法来识别近期在肉牛中进行选择的位点.
- 将GPSM结果与传统的选择性扫描检测方法进行比较.
- 为了研究养牛中选择的基因组结构.
主要方法:
- 在大肉牛数据集上使用GPSM,其中有1100万个归算的SNP.
- 分析了动物生成和SNP等位基因频率之间的关联.
- 雇佣的基于哈普洛型和复合选择性扫描统计.
主要成果:
- 在最近的选中,在两种牛品种中检测到294个独特的位点.
- GPSM在检测近期选择 (<10年) 中具有小的等位基因频率变化时显示出高功率.
- 选择的位置与特定的品种特征有关,如生育能力,母性能力,尸体价值和外套颜色.
- 超过60%的选定位点接近注释基因.
- 识别了数百个早期的选择性扫描,与最近的多基因选择进行了最小的重叠.
结论:
- 当时间基因型数据可用时,GPSM是一种强大的补充方法,用于检测最近的多基因选择.
- 最近的多基因选择和早期的选择性扫描在牛中具有不同的基因组足迹.
- 这项研究突出了养牛选择背后的复杂遗传结构.
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