阿尔茨海默氏症的遗传风险改变了认知健康的中年和老年人认知健康的执行功能障碍
Sarah A Evans1, Elizabeth R Paitel1, Riya Bhasin1
1Department of Psychology, Marquette University, Milwaukee, WI, USA.
Journal of Alzheimer's disease reports
|February 26, 2024
概括
具有Apolipoprotein-E ɛ4等位基因的个体对执行功能的自我意识较差. 这表明,在那些患有阿尔茨海默病遗传风险的人群中,认知能力下降的潜在早期标志物.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 遗传学 遗传学是一种遗传学.
背景情况:
- 主观认知投诉 (SCC) 可能在客观认知下降之前出现,但研究结果各不相同,特别是对于执行功能.
- 早期的认知变化在具有阿波利波蛋白-E ɛ4等位基因的个体中观察到,这是阿尔茨海默病 (AD) 的遗传风险因素.
研究的目的:
- 调查Apolipoprotein-E ɛ4等位基因对主观和客观执行功能之间的对齐的影响.
- 识别风险人群认知能力下降的潜在早期指标.
主要方法:
- 54名健康的中年和老年人完成了主观执行功能 (SEF) 的前额系统行为量表 (FrSBe) 执行功能障碍量表 (EXECDYS).
- 用多个任务来评估目标执行功能,将其缩小为一个单一的因素.
- 参与者被基因型为Apolipoprotein-E ɛ4等位基因 (ɛ4+ = 18).
主要成果:
- 目标执行功能在控制年龄,抑郁和焦虑后显著预测了SEF.
- 阿波脂蛋白-E ɛ4等位基因调节了这种关系,表明自我意识受损.
- 与非运营商相比,e4运营商对其执行职能的自我意识明显不那么准确.
结论:
- 将主观自我评估与客观的神经认知评估相结合,可以检测认知能力下降的早期迹象.
- 这种综合方法可以识别未来认知能力下降的风险较高的个体,特别是那些具有遗传倾向的个体,如e4等位基因.
- 早期识别有助于在最有效的时候及时进行干预.
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