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Elena Kleban^1,2, Derek K Jones^1,3, Chantal M W Tax^4,5

¹CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom.

Imaging neuroscience (Cambridge, Mass.)

|February 26, 2024

概括

扩散张力MRI (DT-MRI) 测量受到相对于磁场的白质 (WM) 纤维方向的影响. 这种定位解释了大脑中DT-MRI数据的显著差异.

科学领域:

神经成像是一种神经成像.
生物物理学的生物物理.
医学物理医学物理

背景情况:

扩散张力MRI (DT-MRI) 是表征白质 (WM) 异性质的一个关键技术.
DT-MRI估计可能会受到与主要磁场相对的组织方向的影响.
了解这种方向依赖对于准确的WM微观结构分析至关重要.

研究的目的:

调查头部与静态磁场 (静电磁场) 相对方向对扩散张力MRI衍生测量的影响.
确定WM微结构是否以及如何影响DT-MRI指标的方向依赖.

主要方法:

模拟WM作为一个两个分区模型来评估方向依赖的理论基础.
进行了"体内"实验,以测量不同头部方向的人体DT-MRI参数.

主要成果:

分区性异构性被证明在扩散张力测量中诱导着方向依赖.
观察到WM纤维的辐射扩散率降低和轴向扩散率增加,其方向是垂直而不是平行.
分数异位变异性根据WM纤维与磁场之间的角度变化高达0.

结论:

与 $相对的WM纤维取向显著影响DT-MRI测量,解释到的差异.$
这种导向效应可以在临床DT-MRI研究中引入变异性,特别是在具有挑战性的场景中,如胎儿/新生儿成像或存在病变.

关键词:

扩散张力成像扩散张力成像纤维的方向是光纤的方向.磁共振成像技术的使用导向的异型性是异型性的.横向放松是一种横向的放松.

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