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Updated: Jul 2, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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异形对称方胺受体的阳离子结合特性

Serap Mert1,2,3, Özden Erdebil2

  • 1Department of Chemistry and Chemical Processing Technology, Kocaeli University, Kocaeli 41140, Turkey.

ACS omega
|February 26, 2024
PubMed
概括

这项研究研究了离子结合的新型方胺 (SQs),发现它们选择性地与化物 (Cl-) 相比,与化物 (Br-) 相结合. 具有pyrrolidine环的跨-DACH衍生物显示出最强的Cl-结合,而没有观察到与化物 (I-) 的相互作用.

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The hybridized nitrogen atom in amines possesses a lone pair of electrons and is bound to three substituents with a bond angle of around 108°, which is less than the tetrahedral angle of 109.5°. However, the C–N–H bond angle is slightly larger at 112°, with a carbon–nitrogen bond length of 147 pm. This carbon–nitrogen bond length of of amines is longer than the carbon–oxygen bond of alcohols (143 pm) but shorter than alkanes’...
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