幻影的粘弹性表征用于超声波弹性学,使用低粘度和高粘度聚合物 (乙烯基醇) 与乙烯基甘醇作为冷保护剂创建
Sapna R Bisht1, Bhanu Prasad Marri1, Jayashree Karmakar1
1Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat 382055, India.
ACS omega
|February 26, 2024
概括
研究人员为超声波弹性学开发了可调节的聚乙烯醇 (PVA) 冰凝幽灵. 这些幻影模仿人类组织的特性,为开发和验证成像技术提供了宝贵的工具.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 超声波弹性学无创性地表征组织机械性质.
- 幻影对于开发,测试和验证弹性图形技术至关重要.
- 创造具有临床相关粘弹性质的幻象是一个持续的研究挑战.
研究的目的:
- 开发可调节的聚乙烯醇 (PVA) 冰凝幽灵,具有临床相关的粘弹性特性.
- 为了研究低粘度和高粘度PVA结合对幻影性质的影响.
- 评估以乙烯糖醇为基础的冷保护剂对幻影同质性和可变性的影响.
主要方法:
- 聚乙醇 (PVA) 冰凝幽灵是使用不同度的PVA和以乙烯基醇为基础的冷保护剂制造的.
- 扫描电子显微镜 (SEM) 分析了幻微结构.
- 幻影的密度,纵向声速,声衰减,剪切模量 (G) 和粘度 (η) 通过剪切波粘性弹性学和凯尔文-沃伊格特模型进行了表征.
主要成果:
- 根据PVA混合物和冷保护剂的存在,SEM揭示了微观结构差异.
- 幻象呈现出临床相关的纵向声速 (1510-1571 m/s) 和衰减指数 (1.23-1.38).
- 取得的剪切模量范围从3.3到17.7 kPa,粘度从2.6到7.3 Pa·s.
- 带有冷保护剂的幽灵体显示较低的G (2.17 ± 0.2 kPa) 和 η (2.0 ± 0.05 Pa·s),并且比没有 (G = 3.93 ± 0.7 kPa; η = 2.6 ± 0.14 Pa·s) 的幽灵体更加均.
- 成功创建了可调整的幻影,具有恒定粘度和不同的剪切模块.
结论:
- 成功开发了具有临床相关粘弹性质的可调节PVA冷凝幻影.
- 使用PVA混合物和冷保护剂可以精确控制幻影机械性能.
- 这些具有良好的特征的幽灵对于推动超声波弹性学研究和应用非常有价值.
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