自然化合物向编程细胞死亡 (PCD) 信号机制来治疗性结肠炎:一篇评论
Bo Chen1, Xinqian Dong2, Jin Long Zhang1
1Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in pharmacology
|February 26, 2024
概括
性结肠炎 (UC) 治疗可以通过向编程细胞死亡 (PCD) 途径来改善. 天然化合物在调节这些途径方面表现有前途,以减少UC患者的炎症和损伤.
科学领域:
- 生物医学科学 生物医学科学
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 性结肠炎 (UC) 是一种具有高耐药性和复发率的慢性炎症性肠病.
- 在UC的慢性炎症可以增加结肠癌的风险.
- 编程细胞死亡 (PCD) 途径对于恒温至关重要,它们的调节失调与UC病变产生有关.
研究的目的:
- 审查编程细胞死亡 (PCD) 在性结肠炎 (UC) 中的作用.
- 探索自然化合物如何针对UC治疗的PCD途径.
- 阐明PCD与UC中的关键信号通路之间的相互作用.
主要方法:
- 使用关键词进行文献搜索:性结肠炎,编程细胞死亡和天然产品.
- 搜索的数据库:PubMed,科学网络和CNKI.
- 综述了过去10年发表的72项研究,重点关注过去5年.
主要成果:
- 异常的PCD信号,包括细胞亡,有助于UC的进展.
- 像贝卡林这样的天然化合物在调节PCD以减少UC炎症方面显示出潜力.
- 在UC中,PCD与NF-κB,Nrf2,MAPK,JAK/STAT,PI3K/AKT,NLRP3,GPX4和Bcl-2等信号通路相互作用.
结论:
- 准PCD途径代表了UC的有前途的治疗策略.
- 自然化合物通过调节PCD为开发新型UC治疗提供了可行的方法.
- 对PCD机制和天然产品相互作用的进一步研究可以导致UC的新药开发.
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