松素诱导了大鼠皮质功能网络组织的剂量依赖性变化
Brian H Silverstein1,2, Nicholas Kolbman1,2,3, Amanda Nelson1
1Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
bioRxiv : the preprint server for biology
|February 26, 2024
概括
松素改变了大鼠的大脑网络动态,因剂量而异地破坏了太-玛合并增加了高频连接. 网络组织中的这些变化可能意味着psilocybin诱导的改变意识状态.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 计算精神病学是一种计算精神病学.
背景情况:
- псилоцибин诱导意识的改变状态,需要动物模型来研究大脑网络动态.
- 以前使用电脑电图 (EEG) 的动物研究缺乏空间分辨率来进行网络分析,并且仅限于较低的马频率.
结论:
- 西可显著改变大脑网络组织,以剂量依赖的方式.
- 高频网络活动,独立于泰达阶段,似乎对于西诱导的改变状态至关重要.
- 这项研究为了解动物模型中的迷幻机制提供了基础.
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