随着SARS-CoV-2的出现,儿科RSV病例数量的增加归因于测试的增加
Brittany A Petros1,2,3,4, Carly E Milliren5, Pardis C Sabeti1,6,7,8
1Broad Institute of MIT and Harvard, Cambridge, MA, USA.
medRxiv : the preprint server for health sciences
|February 26, 2024
概括
增加呼吸道同胞病毒 (RSV) 测试,而不是病毒循环,推动了2021-2023年病例的激增. 检测实践的这种转变,特别是在老年儿童中,导致诊断了较轻的病例,改变了年龄分布,挑战了免疫债务假说.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在COVID-19大流行期间,呼吸道同胞性病毒 (RSV) 发病率下降,随后有报道称复苏.
- "免疫债务"假说表明,幼稚的儿科人口导致RSV风险增加,但证据有限.
- 改变诊断测试实践在感知RSV激增中的作用仍然未被评估.
结论:
- 2021-2023年报告的RSV病例的激增主要归因于诊断测试的增加,不一定是病毒循环的增加.
- 增加的测试导致诊断较轻的严重病例,并改变了诊断患者的年龄分布.
- 这些发现需要重新评估"免责债务"假设,并强调考虑监管中的测试动态.
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