作为对个性化新生儿补充方案的反应,体内生长结果
Lyndsay Harshman1, Elliot Stalter, Silvia Verhofste
1University of Iowa Stead Family Department of Pediatrics.
Research square
|February 26, 2024
概括
协议化 (Na) 补充剂改善了极度早产婴儿的生长和减少了机械通风. 这种方法提高了体重和头周长z-score,但没有增加不良发病率.
科学领域:
- 新生儿医学 新生儿医学
- 儿科内分泌学 儿科内分泌学
- 临床营养学 临床营养学
背景情况:
- 过早出生的婴儿通常需要仔细监测电解质,包括 (Na),以支持生长和发育.
- 既定的补充方案对于管理易受伤害的新生儿的液体和电解质平衡至关重要.
- 尿中的度为指导个性化补充策略提供了一个潜在的生物标志物.
研究的目的:
- 评估以尿液Na度为指导的 (Na) 补充方案对早产婴儿生长参数和发病率的影响.
- 评估在实施协议后,身体重量,头周长和机械通风持续时间的变化.
- 确定该协议是否会影响关键新生儿发病率.
主要方法:
- 追溯队列研究设计,比较婴儿在 (2012-2015) 之前和 (2016-2020) 之后实施议定书.
- 纳入标准:婴儿26 0/7至33 6/7周妊娠年龄 (GA).
- 使用重复测量的统计分析,将线性模型概括为评估随时间的变化,以评估群体内部和群体之间的变化.
主要成果:
- 对于26-29 6/7周的婴儿GA,该方案与8周的平均体重z-score和16周的头周长z-score (p < 0.02) 的增加有关.
- 协议使用与最年轻的早产婴儿 (26-29 6/7 周 GA) 机械通风时间的减少相关.
- 对于30-33 6/7周GA的婴儿,没有观察到对生长的显著影响;高血压,高血,支气管肺功能障碍和败血症的发病率没有受到影响.
结论:
- 协议化 (Na) 补充剂有效改善极度早产婴儿 (26-29 6/7 周 GA) 的生长指标.
- 该方案与此种人群的侵入性机械通风持续时间的显著减少有关.
- 这种Na补充策略可以增强关键的生长参数,但不会增加常见新生儿疾病的风险.
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