感染性并发症与多发性骨髓瘤中BCMA导向疗法的比较
Alexander Lesokhin1, Karthik Nath1, Tala Shekarkhand1
1Memorial Sloan Kettering Cancer Center.
Research square
|February 26, 2024
概括
双特异性抗体 (BsAb) 与多发性骨髓瘤患者的严重感染风险较高,与CAR-T疗法或抗体-药物合物 (ADC) 相比. 化学抗原受体T细胞疗法 (CAR-T) 显示严重感染的风险低于BsAb.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 针对B细胞成熟抗原 (BCMA) 的疗法对于多发性骨髓瘤治疗至关重要.
- 在接受BCMA向治疗的患者中,感染是一个重大挑战.
结论:
- 双特异性抗体 (BsAb) 与多发性骨髓瘤中严重感染的风险更高和更持久有关.
- 感染风险在BsAb治疗时的低胺球蛋白血症和在CAR-T治疗时的中性质减退期间升高.
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