在急诊部对静脉注射乙氨基协议的评估
Aaron B Deutsch1, John D DelBianco2, Patrick Fagan1
1Department of Emergency and Hospital Medicine, Lehigh Valley Health Network/University of South Florida (USF) Morsani College of Medicine, Allentown, USA.
Cureus
|February 26, 2024
概括
静脉注射乙氨基 (IV APAP) 是急诊部 (ED) 的安全有效的非阿片类药物止痛药. 大多数接受IV APAP的患者不需要阿片类药物,这表明它有可能减少阿片类药物在急性疼痛管理中的使用.
科学领域:
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 急性疼痛是急诊室 (ED) 访问的主要原因,需要有效的非阿片类止痛药.
- 口服乙氨基 (APAP) 是常见的,但仅限于能够容忍口服摄入的患者.
- 静脉注射 (IV) APAP提供亲肠道给药,可显著减轻疼痛.
研究的目的:
- 评估在ED接受IV APAP的患者中使用阿片类药物的频率.
- 为了评估IV APAP的安全概况.
- 为了确定是否符合已确定的ED IV APAP协议.
主要方法:
- 在三级护理中接受IV APAP的患者的质量评估,一级创伤中心ED超过三个月.
- 纳入标准:NPO,≥18岁,一次1000毫克IVAPAP剂量.
- 评估了不良反应,ED停留时间 (LOS) 和阿片类药物在IV APAP后四小时内给予.
主要成果:
- 94名患者接受了1000毫克的IV APAP剂量;一名患者患有长期的ED LOS.
- 两名患者同时服用口服药物;没有报告任何不良反应.
- 23.4%的患者在IV APAP的四小时内服用了阿片类药物.
结论:
- 观察到高度符合ED IV APAP协议.
- 在ED环境中,IV APAP证明了安全性和良好的耐受性.
- 在大多数患者中,IV APAP有效地降低了对阿片类止痛药的需求,这表明其在减少ED阿片类药物使用中的有用性.
相关概念视频
Prevention of Further Absorption of Poison
821
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
821
Parenteral Anesthetics: Overview
125
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
125
Acute Pancreatitis II: Clinical Manifestations and Management
124
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
124
Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
Drug Dosage Regimen: Overview
3.5K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.5K
Acute Pharyngitis
666
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
666


