MX1和UBE2L6是糖尿病和动脉样硬化中潜在的元炎基因标
Guisheng Wang1, Rongrong Hua1, Xiaoxia Chen1
1Department of Radiology, Third Medical Center of Chinese PLA General Hospital, Beijing, China.
PeerJ
|February 26, 2024
概括
这项研究确定了MX1和UBE2L6作为糖尿病 (DM) 和动脉样硬化 (AS) 共病的潜在生物标志物. 这些基因可能在元炎症中发挥关键作用,通过微量营养素代谢将DM和AS联系起来.
科学领域:
- 生物化学 生物化学
- 遗传学 遗传学 是一个
- 代谢疾病 代谢疾病
背景情况:
- 糖尿病 (DM) 和动脉样硬化 (AS) 经常同时存在,但潜在的代谢机制仍然不清楚.
- 与代谢相关的分子模式 (MAMPs) 有关,但尚未完全理解.
- 研究共享的分子通路对于理解这种并发症至关重要.
研究的目的:
- 为了确定连接糖尿病和动脉样硬化的共同分子模式和途径.
- 探索特定基因和蛋白质与蛋白质相互作用在并发症中的作用.
- 调查DM和AS同时出现的潜在生物标志物.
主要方法:
- 一种猪模型是使用链毒素 (STZ) 开发的,用于糖尿病诱导和高胆固醇/脂质饮食用于动脉样硬化.
- 对受影响的受试者进行了微阵列基因表达分析.
- 全球和内部的蛋白质与蛋白质相互作用 (PPI) 网络是为差异表达基因 (DEGs) 构建的.
主要成果:
- 动脉样硬化病变发生在诱导DM和超脂血症的猪身上.
- 在DM和AS模型之间确定了103种常见的DEG.
- MX1和UBE2L6成为PPI网络中的关键枢纽蛋白,在受影响的动物中显示过度表达,并与微量营养素代谢和元炎症有关.
结论:
- MX1和UBE2L6是DM和AS共发病的潜在常见生物标志物.
- 这些基因可能通过涉及微量营养素代谢的超炎症过程调解DM和AS之间的联系.
- 需要进一步验证,以阐明MX1和UBE2L6在病理机制中的确切作用.
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