通过皮肤刺激耳道迷走神经会根据刺激参数改变咳的敏感性:对吸入风险的潜在影响
Karen B Ng1,2, Esther Guiu Hernandez2, Jillian Haszard3
1Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Frontiers in neuroscience
|February 26, 2024
概括
通过皮肤进行的耳膜迷走神经刺激 (taVNS) 可以改变咳的敏感性. 在左耳道的更高频率 (80 Hz) taVNS增加了咳的敏感性,这表明对中风康复有潜在的好处.
科学领域:
- 神经学 神经学
- 身体生理学 身体生理学
- 康复医学 康复医学 康复医学
背景情况:
- 通过皮肤进行耳道迷走神经刺激 (taVNS) 是中风肢体康复的安全,有前途的工具.
- 迷走神经通道连接耳朵和喉,这表明taVNS可能会影响咳的敏感性.
- 调节咳敏感性的最佳taVNS参数尚未研究.
研究的目的:
- 调查不同的taVNS参数如何影响咳敏感度.
- 为了比较这些效应与左的标准25 Hz taVNS,通常用于中风康复.
主要方法:
- 一个随机的,单盲,主动控制的,八期的交叉研究与16名健康参与者进行.
- 参与者在八种条件下接受taVNS,这些条件在耳朵 (左/右),刺激区域 (通道/孔查) 和频率 (25 Hz/80 Hz) 中有所不同.
- 咳敏感性是通过使用酸测试来测量自然和抑制咳值的变化.
主要成果:
- 应用于左耳道的80 Hz taVNS显著降低了天然咳值 (-0.16 mol/L,p=0.004),表明与左耳道的25 Hz相比,敏感性增加.
- 在与活性基准相对应的任何刺激条件中,没有观察到对抑制咳值的显著影响.
结论:
- 在左耳道的80 Hz taVNS可能比左耳道的25 Hz taVNS更有效,以改善中风患者的咳敏感性.
- 未来的研究应该探索操纵taVNS参数在模拟控制试验中,以优化其对咳敏感性的影响,以进行中风康复.
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