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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
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来自咖啡因的新型多目标分子作为胆固醇系统的增强剂

Juan Pablo Munafó1, Brunella Biscussi2, Diego Obiol3

  • 1Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur and Consejo Nacional de Investigaciones Científicas y Técnicas, Camino La Carrindanga km 7, Bahía Blanca 8000, Argentina.

ACS chemical neuroscience
|February 26, 2024
PubMed
概括

新的咖啡因衍生物显示出增强的乙胆酶 (AChE) 抑制和尼古丁乙胆受体 (nAChR) 的激活. 这些化合物具有治疗阿尔茨海默病等胆固醇缺乏症疾病的潜力.

关键词:
乙烯基胆 Esterase 的使用.咖啡因类似的咖啡因类型.构造状态 构造状态 构造状态停靠的对接方式电力生理学 电力生理学尼古丁受体是尼古丁的受体.

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