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Updated: Jul 2, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

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开发循环N,O-Aminal嵌入的Bis-tetrahydroisoquinoline类似物作为潜在的DNA化剂

Min Wang1, Tianyang Wang1, Xuemei Qin1,2

  • 1State Key Laboratory of Coordination Chemistry and Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, China.

Organic letters
|February 26, 2024
PubMed
概括

研究人员开发了新的bis-tetrahydroisoquinoline (bis-THIQ) 类似物作为DNA化剂. 这些化合物对人类癌症细胞系表现出强大的抗癌活性,提供了一个有前途的新疗法策略.

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