素补充剂对肝酶水平的影响
Hoda Arefpour1, Niloufar Rasaei2,3, Mohammad Reza Amini1,4
1Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
概括
在成年人中,发现阿斯丁补充剂会增加氨酸转胺酶 (ALT) 水平. 然而,这种抗氧化剂并没有显著影响阿斯巴酸转胺酶 (AST),胺转移酶 (GGT) 或性酸酶 (ALP) 肝酶.
科学领域:
- 营养生物化学 营养生物化学
- 药理学 药理学是指药理学的学科.
- 临床营养学 临床营养学
背景情况:
- 阿斯塔丁是一种强大的抗氧化剂和抗炎性胡卜素,以各种健康益处而闻名.
- 然而,它对肝酶水平的具体影响仍然不完全理解.
研究的目的:
- 进行一项元分析,评估阿斯塔山丁补充剂对肝脏关键酶的影响.
- 具体评估对氨酸转胺酶 (ALT),阿斯巴酸转胺酶 (AST),玛-胺转移酶 (GGT) 和性酸酶 (ALP) 的影响.
主要方法:
- 在主要科学数据库 (PubMed,Scopus,Web of Science,Cochrane,Google Scholar) 进行系统的文献搜索,截至2023年2月.
- 包括五项随机对照试验 (RCT),涉及196名参与者.
- 随机效应模型用于对肝酶变化的加权平均差异 (WMD) 进行聚合.
主要成果:
- 阿斯塔桑补充剂 (6-12毫克/天4-48周) 显著增加了ALT水平 (WMD:1.92 U/L,P=0.03).
- 与安慰剂相比,在AST (WMD:0.72 U/L,P=0.36),GGT (WMD:0.48 U/L,P=0.76) 或ALP (WMD:2.85 U/L,P=0.60) 上没有发现显著影响.
- 这些发现表明,阿斯塔山丁可以提高ALT,但不会改变其他测量的肝酶.
结论:
- 阿斯塔丁补充剂似乎会增加成人ALT度.
- 需要进一步的精心设计的长期RCT来确认这些发现并阐明临床意义.
- 这项研究强调了阿斯塔山丁对ALT的特定作用,需要进一步调查.
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