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Updated: Jul 2, 2025

High-Resolution Mapping of Protein-DNA Interactions in Mouse Stem Cell-Derived Neurons using Chromatin Immunoprecipitation-Exonuclease ChIP-Exo
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阐明EXOSC3-IRE1α相互作用:一个融合的研究,包括计算,体外和体内研究

Ariha Ashraf1, Younis Majeed1, Irfan Gul1

  • 1Department of Biotechnology, University of Kashmir, Srinagar, India.

Journal of biomolecular structure & dynamics
|February 26, 2024
PubMed
概括

研究人员确定EXOSC3是IRE1α的结合伙伴,它是展开蛋白质反应 (UPR) 中的关键参与者. 这一发现表明IRE1α和EXOSC3之间的功能交叉声,可能会影响ER压力期间的UPR动态.

关键词:
细胞内膜网膜 (ER) 应激压力外体组合蛋白3外体组合蛋白3这就是IRE1α.蛋白质数据库 蛋白质数据库不折叠的蛋白质反应反应

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Regulation of the Unfolded Protein Response01:31

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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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