对于急性瘤性胰腺炎的一个核心结果:东方创伤外科协会修改了德尔菲方法的共识研究
Michael S Farrell1, Adanan Alseidi, Saskya Byerly
1From the Division of General and Trauma Surgery, Department of Surgery (M.S.F., J.G.), Lehigh Valley Health Network, Allentown, Pennsylvania; Department of Surgery (A.A.), University of California, San Francisco, California; Division of Trauma/Surgical Critical Care, Department of Surgery (S.B.), University of Tennessee Health Science Center, Memphis, Tennessee; Department of Gastroenterology and Hepatology (P.F.), Amsterdam University Medical Centers, University of Amsterdam/Free University; Amsterdam Gastroenterology Endocrinology Metabolism (P.F., R.P.V.), Research Institute; Cancer Center Amsterdam (P.F., R.P.V.), Amsterdam, the Netherlands; Department of Surgery (F.A.G.), Institution Christiana Care Health Services, Newark, Delaware; Department of Surgery (K.H.), University of Washington, Seattle, Washington; National Pancreas Foundation (D.J.), Chicago, Illinois; Department of Trauma, Emergency Surgery and Surgical Critical Care (C.L.), Massachusetts General Hospital, Boston, Massachusetts; Department of Surgery (N.M.), Wake Forest University, Winston Salem, North Carolina; Department of Surgery (B.R.H.R.), Harborview Medical Center, Seattle, Washington; National Pancreas Foundation (A.R.), Rockland, New York; Division of Gastroenterology, Department of Medicine (V.K.S.), Johns Hopkins Medical Institutions, Baltimore, Maryland; Regional Hepato-Pancreato-Biliary Unit (A.K.S.), Manchester Royal Infirmary, Manchester, England; Division of Gastroenterology and Hepatology (S.S.V.), Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine (G.T.), University of Minnesota Medical Center, Minneapolis, Minnesota; Department of Surgery (B.C.V.), Stanford University School of Medicine, Stanford, California; Department of Gastroenterology and Hepatology (R.P.V.), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Department of Surgery (D.D.Y.), Denver Health, Denver, Colorado; and Department of Surgery (R.B.G.), University of Alabama at Birmingham, Birmingham, Alabama.
专家们为急性死性胰腺炎 (ANP) 管理制定了一个核心结果集 (COS). 这一标准化套件将通过实现数据聚合和减少ANP研究中的偏见来改善未来的研究.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 手术研究的研究.
- 临床试验方法论 临床试验方法论
背景情况:
- 在过去的二十年中,急性死性胰腺炎 (ANP) 的治疗方法有了显著的进化.
- 关键的进步包括更少的侵入性技术,优化的干预时间,以及改进的营养和抗菌战略.
- 现有的研究缺乏标准化的结果指标,这阻碍了数据的比较和聚合.
研究的目的:
- 为急性死性胰腺炎 (ANP) 研究制定一个核心结果集 (COS).
- 建立一个最小的,必要的结果集,以便统一地收集和分析数据.
- 尽量减少报告偏见,并促进未来的元分析和临床实践指南.
主要方法:
- 一个经过修改的Delphi流程,涉及19名ANP内容专家.
- 专家们使用9点的利克特等级在四轮中匿名对拟议的结果进行了评分.
- 共识被定义为>70%的得分在7-9之间,<15%在1-3之间.
主要成果:
- 在19名专家中,有16名专家完成了这项研究.
- 最初评估了43个结果,其中16个达到了共识.
- 最终的COS包括死亡率,器官衰竭,并发症,干预措施和社会因素.
结论:
- 成功建立了ANP管理的基于共识的核心成果集 (COS).
- 这个COS将在未来的ANP研究中标准化结果报告.
- 标准化结果将支持数据聚合,以便进行可靠的统计分析和基于证据的临床实践.
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Assessment:


