印度尼西亚死产的发病率和头三个月的风险因素
Mirani Ulfa Yusrika1, Adly Nanda Al Fattah1,2, Raden Aditya Kusuma1,3
1633485 Indonesian Prenatal Institute , Jakarta, Indonesia.
Journal of perinatal medicine
|February 26, 2024
概括
这项研究发现,包括慢性高血压和高平均动脉压在内的几种第一季度标志物,显著增加了印尼妇女死产风险. 早期查可以帮助识别患死产风险较高的怀孕.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 生殖健康 生殖健康
背景情况:
- 死亡出生仍然是一个重要的全球健康问题,对印度尼西亚等特定人口的风险因素的数据有限.
- 第一个三个月的查条件,如孕前,提供了一个机会,以识别其他妊娠并发症,包括死产.
研究的目的:
- 调查印尼妇女死产的发生率.
- 为了确定11-13周怀孕时死产的母亲的生物物理,超声波和生物化学风险因素.
主要方法:
- 一项回顾性队列研究,涉及印尼雅加达的1643名孕妇.
- 收集的数据包括母亲的特征,平均动脉压 (MAP),子宫动脉脉动指数 (UtA-PI),眼睛峰值比率 (Oph-PR) 和胎盘生长因子 (PlGF).
- 使用后勤回归分析来确定死胎的风险因素,分类为与胎盘功能障碍相关的或不相关的.
主要成果:
- 死产发病率为0.79% (13例),其中一半以上与胎盘功能障碍有关.
- 经过调整后的分析显示,死胎和慢性高血压 (aOR 24.41),先前的孕前 (aOR 15.79),MAP>101.85 (aOR 26.67),Uta-PI>1.90 (aOR 10.68) 和PlGF <28.77 pg/mL (aOR 18.60) 之间存在显著的关联.
结论:
- 在这个印尼人口中,死产的发生率与发达国家相当.
- 常规的第一季度查标记子宫前症也与死产风险有关,突出了它们对更广泛风险评估的潜力.
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