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DNA-PK控制了阿波罗进入领先端端粒的访问权

Ceylan Sonmez1, Beatrice Toia1, Patrik Eickhoff2

  • 1Department of Biomedical and Clinical Sciences, Linköping University, Linköping 58 183, Sweden.

Nucleic acids research
|February 26, 2024
PubMed
概括

DNA-PK通过与核酶阿波罗结合来调节前端端粒切除. 这种相互作用依赖于DNA-PKcs激酶活性和酸化,将阿波罗定位在DNA末端,防止端粒融合.

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