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Updated: Jul 2, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

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通过G-四方体介导的基因组不稳定性推动了SNVs在癌症中的作用

Tilmann Richl1, Jochen Kuper1, Caroline Kisker1

  • 1Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Wuerzburg, Wuerzburg 97080, Germany.

Nucleic acids research
|February 26, 2024
PubMed
概括

G-四重复 (G4) DNA结构与基因组不稳定性和癌症有关. 这项研究表明,较高的G4含量与癌症相关变体增加和生存率降低相关,这表明G4s是治疗点.

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