种族群体之间的死亡率和成年人中MASLD的结果差异:一个多中心研究
Majd B Aboona1, Claire Faulkner1, Pooja Rangan2
1Department of Internal Medicine, University of Arizona College of Medicine, Phoenix, Arizona, USA.
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 不成比例地影响少数民族群体,导致较高的死亡率和肝脏相关事件. 患有MASLD的瘦个体也面临更高的风险,突出了针对性干预的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 显著比例的MASLD病例发生在瘦个体中,这是一种经常被研究不足的人口统计学.
- 有限的数据存在于种族多样化的人口中MASLD的结果.
研究的目的:
- 在多样化的患者队列中调查MASLD的自然史.
- 识别和分析MASLD结果中的种族差异.
- 将MASLD结果按体重指数类别分层.
主要方法:
- 从2012-2022年对MASLD患者进行的回顾性多中心研究.
- 对关键结果的分析,包括死亡率,肝硬化,心血管疾病,糖尿病 (DM),肝脏相关事件 (LREs) 和癌症.
- 利用竞争风险和考克斯比例危险回归来进行结果建模.
主要成果:
- 该研究包括超过51000名患者,其中9.6%被确定为瘦身.
- 与欧洲祖先相比,西班牙裔,非洲裔和美洲原住民/阿拉斯加人的祖先的死亡率,LREs和DM发病率较高.
- 与非瘦身患者相比,瘦身MASLD患者的死亡率和LREs增加.
结论:
- 少数民族 (美洲原住民/阿拉斯加人,西班牙裔,非洲人) 与欧洲人相比,面临着明显更高的死亡率和来自MASLD的LREs.
- 精益 MASLD 患者,特别是来自特定族群的患者,需要进一步调查和有针对性的干预措施来减轻风险.
- 解决种族差异对于改善MASLD的临床结果至关重要.
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