杆菌对circPGD进行上调,并促进胃癌的发展
Wenjun Zhao1,2, Zhendong Yao1, Jia Cao3
1The Affiliated Yixing Hospital of Jiangsu University, Wuxi, 214200, Jiangsu, China.
杆菌 (H. pylori) 感染增加了circPGD的表达,通过增强细胞增殖,迁移和炎症来促进胃癌,同时抑制了细胞亡. CircPGD是H. pylori相关的胃癌的潜在治疗标.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 杆菌 (H. pylori) 是胃肠道癌症的主要原因,这是由于其独特的致病机制.
- 循环RNAs (circRNAs) 越来越多地被认为是它们在癌症病理生理学中的作用.
- 胃癌发展中的H. pylori和circRNAs之间的相互作用仍未得到充分研究.
研究的目的:
- 为了研究H. pylori和circRNAs之间的相互作用.
- 探索circPGD在H.pylori相关的胃癌中的作用.
- 了解H. pylori和circRNAs如何共同导致胃癌.
主要方法:
- 定量逆转录聚合酶连锁反应 (qRT-PCR) 来检测circPGD表达.
- 细胞增殖试验 (殖民地形成,CCK-8) 和迁移试验 (Transwell).
- 流细胞测量用于细胞亡测量和西部斑块用于蛋白质分析.
主要成果:
- 杆菌感染显著增加了人体细胞中的circPGD表达.
- 增加circPGD表达通过增强细胞增殖和迁移促进了胃癌的进展.
- 由H. pylori诱导的circPGD还增强了炎症反应,并抑制了亡.
结论:
- CircPGD在与H. pylori相关的胃癌中发挥着关键作用.
- CircPGD代表了H.pylori诱导的胃癌的一个潜在的新疗法标.
更多相关视频
10:44One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode
Published on: June 18, 2016
09:05High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
Published on: November 21, 2014
相关概念视频
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
