从头发中获得的大麻素水平,自我报告的使用和与大麻相关的问题之间的关联
Emese Kroon1,2, Janna Cousijn3,4, Francesca Filbey5
1Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands. kroon@essb.eur.nl.
Psychopharmacology
|February 26, 2024
概括
头发中的大麻素水平可以检测到大麻的使用,但与自我报告的数量或问题没有相关性. 这表明头发分析对于检测是有用的,而不仅仅是用于量化大麻暴露.
科学领域:
- 大麻素科学是关于大麻素的科学.
- 法医毒理学 法医毒理学
- 成研究研究成研究
背景情况:
- 增加大麻功效和使用需要准确的暴露测量.
- 在新合法化的市场上,对大麻素暴露的评估至关重要.
研究的目的:
- 评估头发大麻素度 (3个月累计暴露) 和自我报告的大麻使用之间的关联.
- 评估头发大麻素水平与自我报告的大麻使用量和相关问题.
主要方法:
- 分析了74名近日大麻使用者的头发样本,使用LC-MS/MS和GC-MS/MS.
- 量化D9-THC,CBD和CBN;通过THC-COOH验证THC消耗.
- 收集了关于大麻数量,功效和使用相关问题的自我报告数据.
主要成果:
- Δ9-THC头发度与自我报告的强度相关,而不是使用量.
- 头发大麻素度与自我报告的大麻使用量没有关联.
- 自我报告的强度与戒断/渴望相关;自行报告的量与使用问题相关.
结论:
- 头发大麻素分析可以有效地检测近日使用者的大麻使用情况.
- 单独的头发分析不足以量化大麻素暴露,因为与自我报告缺乏相关性.
- 需要进一步研究,将头发与其他矩阵 (例如血) 进行比较,以验证头发分析.
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