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千伏和质量参考mAs对基于CT的衰减校正在Lu SPECT/CT成像中的影响:一个幻影研究

Maikol Salas-Ramirez¹, Julian Leube², Michael Lassmann²

¹Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. E_Salas_M@ukw.de.

|February 26, 2024

概括

千伏峰值 (kVp) 和质量参考 mAs (QRM) 设置对定量177Lu SPECT/CT成像的影响最小. 降低kVp和QRM可以降低辐射剂量 (CTDIvol),而不会显著影响精度,优化SPECT/CT协议.

科学领域:

核医学是一种核医学.
医学成像物理医学成像物理

背景情况:

在SPECT/CT中精确量化活动依赖于基于CT的减弱校正 (CT-AC).
千伏峰值 (kVp) 和质量参考 mAs (QRM) 对CT-AC和辐射剂量 (CTDIvol) 的影响需要对177Lu SPECT/CT进行系统评估.

研究的目的:

为了研究不同kVp和QRM对CT-AC对177Lu SPECT/CT的影响.
评估由此产生的活性量化和辐射剂量变化.

主要方法:

用不同的kVp/QRM设置获得了70个电子密度幻影的低剂量CT扫描.
生成了177Lu衰减图 (μ-maps),并比较测量与理论衰减值.
计算了活动量化变化,评估了μ-map噪声,并使用不同的重建算法评估了SPECT/CT成像.

主要成果:

在大多数组织中,测量和理论μ值之间的相对误差为<6%,除了肺 (18%-36%).
结果活动量化变化在大多数组织中为<2.3%,肺部为-3.5%.
与较高的设置 (3.6 mGy) 相比,较低的kVp/QRM设置减少了CTDIvol (0.9 mGy),对μ-map噪声的影响最小.

结论:

kVp和QRM对定量177Lu SPECT/CT成像准确度的影响很小.
选择较低的kVp和QRM值可以有效地降低患者的辐射剂量 (CTDIvol).
xSPECT 量子重建显示了基于 SPECT 的活动量化性能优越.

关键词:

177Lu SPECT/CT/CT 标签: 标签: 标签: 标签: 标签: 标签:减弱校正的纠正减弱校正的纠正在CTDIvolvol中定量化SPECT/CTCT 测试方法

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