在振动微针和低频声系统之间对透效应的比较研究
Tingting Liu1, Kai Chen2, Zhigang Yan1
1School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou, 310018, China.
Drug delivery and translational research
|February 26, 2024
概括
振动式微针显著提高药物透率,比低频超声更高. 优化的微针设置实现了四甲基酸 (TMPH) 皮肤透率的41.92倍增加,超越了超声波的性能.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
- 药物运输 药物运输 药物运输
背景情况:
- 通过皮肤递送药物在口服或注射途径上具有优势.
- 研究了微针和超声波等物理方法,以克服皮肤的屏障特性.
- 提高药物透率对于有效的透皮疗法至关重要.
研究的目的:
- 为了比较振动微针和低频超声波在增强通过皮肤透药物的有效性.
- 调查微针和超声波介导药物输送的最佳参数.
- 使用这些物理方法评估四甲基酸 (TMPH) 通过皮肤传递的效果.
主要方法:
- 使用瓦利亚-奇恩双腔扩散细胞进行体外透研究.
- 通过大鼠皮肤通过皮肤输送四甲基酸 (TMPH).
- 高性能液体色谱 (HPLC) 用于量化TMPH度.
- 微针 (高度,频率,时间) 和超声波 (距离,时间) 参数的系统变化.
主要成果:
- 与超声波相比,振动微针显示出TMPH皮肤透性的优越增强.
- 最佳的微针参数 (更大的针,更高的频率,3分钟暴露) 导致累积透率增加了41.92倍.
- 低频超声波与3mm角到皮肤距离和3分钟的暴露显示TMPH透率增加了4.34倍.
结论:
- 振动微针和低频超声波都有效地提高了通过皮肤的药物透率.
- 振动微针技术为促进TMPH通过皮肤透提供了一种更有效的方法.
- 基于微针的系统对先进的透皮药物递送应用更有前途.
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