内 Carotid 动脉 狭窄 和 Ipsilateral 亚视网膜 状 沉积物
Emanuel Mordechaev1, Jason J Jo1, Samuel Mordechaev1
1New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States.
Investigative ophthalmology & visual science
|February 26, 2024
概括
亚视网膜状体沉积物 (SDD) 与内动脉狭窄症 (ICA) 有关. 中度或重度的ICA狭窄会增加患上ipsilateral SDDs的风险,这表明与眼部低 perfusion 的联系.
科学领域:
- 眼科和神经病学 眼科和神经病学
- 血管医学 血管医学
背景情况:
- 亚视网膜状体沉积 (SDD) 与与年龄相关的黄斑变性 (AMD) 和系统性血管病变 (如心肌梗塞和缺血性中风) 有关.
- 内动脉 (ICA) 狭窄会导致大脑和眼睛的血液流量减少 (低输血).
研究的目的:
- 为了研究由内动脉 (ICA) 狭窄引起的眼睛低 perfusion 和在缺血性中风患者中存在 ipsilateral subretinal drusenoid 沉积物 (SDD) 的关系.
主要方法:
- 一项横截面研究包括28名缺血性中风患者,他们接受了头部和部的计算机断层扫描 (CT) 来评估ICA狭窄.
- 用光谱域光学连贯性断层扫描 (SD-OCT) 来评估软,SDD和冠状腺厚度 (CTh).
- 进行了统计分析,包括单变量和多变量逻辑回归,以确定SDD的风险因素.
主要成果:
- 适度或较大的ICA狭窄 (≥50%-69%) 与ipsilateral胆道细化 (P = 0.021) 和ipsilateralSDDs (P = 0.005) 有意义地相关.
- 轻度ICA狭窄 (≥1%-49%) 与ipsilateralSDDs没有显著的关联.
- 在多变量回归中,老年和中度或较大的ICA狭窄被确定为ipsilateralSDD的独立风险因素.
结论:
- 中度至重度的ICA狭窄症与ipsilateral SDD和胆道细化有很强的联系,支持眼球低 perfusion 作为SDD发展的机制.
- SDD可以作为有价值的生物标志物,用于识别患有缺血性中风和其他血管疾病风险的患者.
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