与COVID-19相关的急性损伤和纵向结果
Abinet M Aklilu1,2, Sanchit Kumar1, James Nugent1,3
1Clinical and Translational Research Accelerator, Yale University, New Haven, Connecticut.
JAMA internal medicine
|February 26, 2024
概括
幸存者COVID-19相关的急性损伤 (AKI) 有更好的长期结局. 这项研究发现,与其他AKI组相比,COVID-AKI患者的重大脏不良事件 (MAKE) 和死亡率较低.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- COVID-19与急性损伤 (AKI) 的高发病率有关.
- 在COVID-19相关AKI (COVID-AKI) 后的长期功能尚不清楚.
- 以前的报道表明,在COVID-AKI后的最初几个月里,功能迅速下降.
研究的目的:
- 为了评估经历COVID-AKI的患者的长期脏结果.
- 为了比较COVID-AKI幸存者的主要不良事件 (MAKE) 与其他AKI队列.
主要方法:
- 使用电子健康记录进行了回顾性的纵向多中心队列研究.
- 包括在大流行期间患有AKI的住院成年患者 (COVID-AKI) 和历史流感相关的AKI队列.
- 出院后长达2年的随访,分析MAKE (死亡率,eGFR下降或功能衰竭).
主要成果:
- 这项研究分析了9624名AKI患者,包括987名COVID-AKI患者.
- 与其他AKI (aHR,0.67) 和流感AKI组相比,COVID-AKI患者的MAKE率较低.
- 这种MAKE的减少是由较低的全因死亡率 (aHR,0.31) 和恶化的功能 (aHR,0.78) 驱动的.
结论:
- 在COVID-AKI中幸存下来的住院患者显示长期不良脏结果的发生率较低.
- 与其他AKI群体相比,COVID-AKI幸存者经历了显著降低的死亡率和功能下降.
- 研究结果表明,COVID-AKI幸存者的长期脏预后可能比最初担心的更好.
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