与代谢功能障碍相关的脂肪性肝病的间歇性禁食方案:随机对照试验的系统审查和网络元分析
Mohamed T Abuelazm1, Islam Mohamed2, Ahmed Naeem3
1Faculty of Medicine, Tanta University, Tanta, Egypt.
European journal of gastroenterology & hepatology
|February 26, 2024
概括
间歇性禁食 (IF) 对代谢功能障碍相关的脂肪性肝病 (MASLD) 产生多种影响. 虽然一些IF疗法可以改善肝硬度和脂肪,但建议针对患者量身定制的方法来实现最佳的MASLD管理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是与代谢综合征相关的日益严重的全球健康问题.
- 在MASLD中,肝脏脂肪的积累有助于肝损伤和疾病的进展.
- 间歇性禁食 (IF) 正在探索其减轻代谢障碍和改善肝脏健康的潜力.
研究的目的:
- 系统地审查和网络元分析随机对照试验 (RCT),比较不同IF疗法在治疗MASLD中的疗效.
- 确定哪些IF策略为关键的MASLD临床结果提供了最显著的好处.
- 为MASLD患者提供个性化的IF干预提供基于证据的指导.
主要方法:
- 在主要数据库 (PubMed,EMBASE,WOS,SCOPUS,Cochrane) 进行了系统的搜索,直到2023年4月10日.
- 八个涉及635名参与者的RCT被纳入了网络元分析.
- 数据使用R软件进行分析,使用平均差异与95%置信区间来评估连续结果.
主要成果:
- 5:2饮食显著降低了肝硬度 (MD, -0.32;95% CI, -0.55至 -0.09).
- 时间限制的养显著改善了通过受控衰减参数得分 (MD, -39.83; 95% CI, -64.78至 -14.87) 测量的肝肥胖症.
- 替代性禁食日在瘦身量,腰围和减肥等人体测量指标上有所改善 (P < 0.05).
结论:
- 间歇性禁食疗法对MASLD的临床结果有不同的影响,没有任何一种疗法被证明是普遍优越的.
- 特定的IF协议,如5:2饮食和时间限制的食,有望改善肝脏的特定参数.
- 对间歇性禁食的个性化,针对患者量身定制的方法对于有效的MASLD管理至关重要.
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